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 Formulary Chapter 24: Leeds Children's Hospital Formulary - Full Chapter
Notes:

The Leeds Children's Hospital Formulary is laid out in BNF chapter order. There are custom indexes for the following specialist areas:

Paediatric Intensive Care Unit (PICU)
Neonatal Intensive Care Unit (NICU)
Paediatric Cardiology

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24.10  Expand sub section  Musculoskeletal and joint diseases (paediatric)
Abatacept
(paediatrics)
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Formulary
Red
High Cost Medicine
 
Link  LTHT: patient information leaflet (abatacept)
Link  Paediatric rheumatology administration guide (abatacept)
Link  Paediatric Rheumatology prescribing guidance: abatacept
   
Anakinra
(paediatrics)
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Formulary
Red
  • treatment of cytokine release syndrome following CAR-T therapy
 
Link  Paediatric Rheumatology prescribing guidance - Anakinra
   
Azathioprine
(paediatrics)
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Formulary
Amber 3
  • There are a number of different indications for azathioprine. Please see here for other indications.
 
Link  Amber drug guidance: azathioprine in children with rheumatological conditions
   
Baclofen
(paediatrics)
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Formulary
High Cost Medicine
 
   
Canakinumab
(paediatrics)
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Formulary
Red
 
Link  Paediatric Rheumatology prescribing guidance - canakinumab
   
Ciclosporin
(paediatrics)
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Formulary
Amber 3
  • There are a number of different indications for ciclosporin. Please see here for other indications. 
  • Link  Amber Drug Guidance for paediatric rheumatology (ciclosporin)
    Link  LTHT Patient Information Leaflet - paediatric rheumatology
       
    Cyclophosphamide
    (paediatrics)
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    Formulary
    Amber 2
     
    Link  Paediatric Rheumatology administration guide: cyclophosphamide
    Link  Paediatric Rheumatology prescribing guidance: Cyclophosphamide IV
    Link  Patient Information Leaflet: cyclophosphamide non-oncology indications
       
    Etanercept
    (paediatrics)
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    Formulary
    Red
     
    Link  Paediatric Rheumatology prescribing guidance: Etanercept
    Link  PIL: biosimilar etanercept (children) (LTHT access only)
       
    Hydroxychloroquine
    (paediatrics)
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    Formulary
    Amber 2

    There are several indications for hydroxychloroquine; please see here for further indications.

     
    Link  Amber Drug Guidance - for rheumatological conditions in children
    Link  LTHT PIL: hydroxychloroquine in children
       
    Methylprednisolone
    (paediatrics)
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    Formulary  
    Link  Paediatric rheumatology administration guide (methylprednisolone)
       
    Rituximab (and biosimilars) (MabThera, Rixathon, Truxima)
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    • There are multiple indications for rituximab. Contact a specialist pharmacist for further details

      LTHT use biosimilar rituximab for children:
    • Truxima® for all paediatric patients (also used for adult non-haematology patients)
    • Rixathon® (for adult haematology)
       

     

    • NHSE commission for anti-NMDAR autoimmune encephalitis (all ages): SSC1625
     
    Link  Paediatric rheumatology administration guide (rituximab)
    Link  Paediatric Rheumatology prescribing guidance: Rituximab
    Link  PIL: biosimilar rituximab (children) (LTHT access only)
       
    Sulfasalazine
    (paediatrics)
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    Formulary
    Amber 3
     
    Link  Amber Drug Guidance - sulfasalazine (paediatric rheumatology)
    Link  LTHT: sulfasalazine - interference with ALT assay (updated Oct 17)
    Link  Patient Information leaflet: sulfasalazine in juvenile idiopathic arthritis in children and young people
       
    Tocilizumab
    (paediatrics)
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    Formulary
    Red
    High Cost Medicine
    • treatment of cytokine release syndrome following CAR-T therapy
     
    Link  Paediatric rheumatology administration guide (tocilizumab)
    Link  Paediatric Rheumatology prescribing guidance: tocilizumab
    Link  Tocilizumab for Takayasu arteritis (through Children’s Policy)
       
    Triamcinolone
    (paediatrics)
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    Formulary  
    Link  PIL: Corticosteroid injections for juvenile arthritis: Information for Parents/Carers/Young People
       
     ....
     Non Formulary Items
    Asfotase alfa

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
    • Highly Specialised Service not commissioned in Leeds - refer to expert centre
    • NHSE SSC1836 (Mar 18) provides information for trusts that are not expert centres - shared care arrangements (via Medicines Advice 65377)
    Link  NICE HST6: Asfotase alfa for treating paediatric-onset hypophosphatasia
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    SMC
    Scottish Medicines Consortium
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Green

    Medicines which are appropriate for initiation and ongoing prescribing in both primary and secondary care.  

    Amber 1

    Amber Level 1- Specialist Recommendation
    These medicines are considered suitable for GP prescribing following specialist recommendation.

    There is no requirement for full Amber Drug Guidance. Generic Amber Level 1 Drug Guidance detailing responsibilities and information sources is available here
      

    Amber 2

    Amber Level 2- Specialist Initiation but no monitoring requirements
    These medicines are considered suitable for GP prescribing following specialist initiation, including titration of dose and assessment of efficacy.
    Some Amber Level 2 products will have an associated Amber Level 2 Drug Guidance document, available by clicking on the traffic light symbol to the right of the drug name. If this is not available, generic Amber Level 2 Drug Guidance is available here  

    Amber 3

    Amber Level 3- Specialist Initiation with ongoing monitoring requirements (Full Amber Drug Guidance required)
    Medicines that should be initiated by a specialist, and which require significant monitoring on an ongoing basis. Full agreement to share the care of each specific patient must be reached under the amber drug agreement, and Amber Drug Guidance must be provided to the GP (available by clicking on the traffic light symbol to the right of the drug name).   

    Red

    Guidance on the responsibilities for Red Drugs can be found here. Red Drugs would usually by prescribed by the hospital for the duration of the course. Primary care prescriber initiation or continuation of treatment not recommended except by Specialist GP and community paediatric prescribing.   

    Grey

    Grey Drugs are locally-agreed medicines which are only recommended for restricted use within the Leeds Health Economy.   

    Black

    These drugs are not recommended for use within the Leeds Health Economy  

    Multiple

    Products shown as blue have different Traffic Light List classifications dependent on indication. See the accompanying text next to the product for further information the indications for which it has a Traffic Light List classification.  

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