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 Formulary Chapter 24: Leeds Children's Hospital Formulary - Full Chapter
Notes:

The Leeds Children's Hospital Formulary is laid out in BNF chapter order. There are custom indexes for the following specialist areas:

Paediatric Intensive Care Unit (PICU)
Neonatal Intensive Care Unit (NICU)
Paediatric Cardiology

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24.05  Expand sub section  Infections (paediatric)
Aciclovir
(paediatrics)
View SPC online View childrens BNF
Formulary
  • Oral - follow BNFc
  • IV - follow dosing and administration guide
 
Link  PICU Prescribing and Administration Guide (aciclovir)
Link  BNFc oral dosing information (aciclovir)
Link  National Paediatric IV Administration Guide (Medusa) - aciclovir
   
Amikacin (Amikin)
( paediatrics)
View adult BNF View SPC online View childrens BNF
Formulary  
Link  Leeds Cystic Fibrosis inhaled therapy guidelines (adults and children)
Link  Leeds Cystic Fibrosis IV antibiotics (adults and children)
   
Amoxicillin
(paediatrics)
View SPC online View childrens BNF
Formulary
  • Oral - follow BNFc
  • IV - follow prescribing and administration guide
 
Link  PICU Prescribing and Administration Guide (amoxicillin)
Link  BNFc oral dosing information (amoxicillin)
Link  LTHT Cystic Fibrosis Oral Antibiotics guidelines (adults and children)
Link  National Paediatric IV Administration Guide (Medusa) - amoxicillin
   
Amphotericin (liposomal) (AmBisome)
(paediatrics)
View SPC online View childrens BNF
Formulary
High Cost Medicine
 
Link  Drug Safety Update (July 2018): Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused
Link  PICU Prescribing and Administration Guide (AmBisome)
Link  LTHT Cystic Fibrosis Inhaled therapy (adults and children)
Link  LTHT Cystic Fibrosis IV Antibiotic guidelines (adults and children)
   
Azithromycin
( paediatrics)
View adult BNF View SPC online View childrens BNF
Formulary  
Link  Leeds Cystic Fibrosis oral antimicrobial guidelines
   
Aztreonam
(paediatrics)
View SPC online View childrens BNF
Formulary

Aseptics product available:

  • 5mg to 20mg per mL in sodium chloride 0.9% bag (cystic fibrosis) (preparation risk rating: amber)
  • 100mg per mL in water for injections (general paediatrics) (preparation risk rating: amber)
  • Severe shortages: Fully restricted antimicrobial.
  • Microbiology codes not required for cystic fibrosis patients (June 2017)
 
Link  Ongoing supply shortage - alternatives
Link  LTHT aseptics order form (paediatric CF)
Link  LTHT Cystic Fibrosis Inhaled Therapy (adults and children)
Link  LTHT Cystic Fibrosis IV Antibiotic guidelines (adults and children)
   
Benzylpenicillin
(paediatrics)
View SPC online View childrens BNF
Formulary  
Link  BNF-C dosing: benzylpenicillin
Link  Paediatric IV Guide - benzylpenicillin
   
Caspofungin
( paediatrics)
View adult BNF View SPC online View childrens BNF
Formulary  
   
Cefaclor
( paediatrics)
View adult BNF View SPC online View childrens BNF
Formulary  
Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines
   
CefoTAXime
(paediatrics)
View SPC online View childrens BNF
Formulary  
Link  BNFC dosing (cefoTAXime)
   
cefOXITin
( paediatrics)
View adult BNF View SPC online View childrens BNF
Formulary  
   
CefTAZidime
(paediatrics)
View SPC online View childrens BNF
Formulary  
Link  PICU Prescribing and Administration Guide (cefTAZidime)
Link  BNFc dosing (cefTAZidime)
Link  CVC infection guideline for children on TPN
Link  LTHT Cystic Fibrosis IV antibiotics guidelines (adults and children)
   
CefTRIAXone
(paediatrics)
View SPC online View childrens BNF
Formulary  
Link  BNFC dosing (cefTRIAXone)
Link  IM administration guidance (cefTRIAXone)
   
CeFUROXime
(paediatrics)
View SPC online View childrens BNF
Formulary  
Link  PICU Prescribing and Administration Guide (cefuroxime)
Link  LTHT Cystic Fibrosis IV antibiotics guideline (adults and children)
Link  National Paediatric IV Administration Guide (Medusa) - cefuroxime
   
Cidofovir (Vistide)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
  • Adenovirus and BK virus in children 
  • Link  LTH Paed Oncology guidance: adenovirus and polyoma BK virus
       
    Ciprofloxacin
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
    Link  Drug Safety Update (Mar 2019) Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
    Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines
    Link  UK Guidelines: IBD in children
       
    Clarithromycin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
  • Oral - BNFc
  • IV - follow prescribing and administration guide 
  • Link  PICU Prescribing and Administration Guide (clarithromycin)
    Link  BNFc oral dosing information (clarithromycin)
    Link  LTHT Cystic Fibrosis Oral antimicrobial therapy (adults and children)
       
    Clindamycin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  National Paediatric IV Administration Guide (Medusa) - clindamycin
    Link  LTHT Cystic Fibrosis Oral antimicrobial therapy (adults and children)
       
    Co-amoxiclav
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  LTHT Cystic Fibrosis Oral antimicrobial therapy (adults and children)
    Link  National Paediatric IV Administration Guide (Medusa) - co-amoxiclav
       
    Co-trimoxazole
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
    Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines (adults and children)
       
    Daptomycin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  National Paediatric IV Administration Guide (Medusa) - daptomycin
       
    Doxycycline
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted  
    Link  Leeds Cystic Fibrois Oral antimicrobial guidelines (adults and children from age 8)
       
    Ethambutol
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
    Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines (adults and children)
       
    Flucloxacillin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    • Oral - follow BNFc
    • IV - follow prescribing and administration guide
     
    Link  PICU Prescribing and Administration Guide (flucloxacillin)
    Link  BNFc oral dosing information (flucloxacillin)
    Link  National Paediatric IV Administration Guide (Medusa) - flucloxacillin
    Link  LTHT Cystic Fibrosis IV antibiotics guideline (adults and children)
    Link  LTHT Cystic Fibrosis Oral antibiotics guideline (adults and children)
    Link  LTHT: Cardiac Surgery in Children - Guideline for antimicrobial prophylaxis
       
    Fluconazole
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    • Oral - follow BNFc
    • IV - follow prescribing and administration guide
     
    Link  PICU Prescribing and Administration Guide (fluconazole)
    Link  BNFc oral dosing information (fluconazole)
    Link  LTHT Cystic Fibrosis IV Antimicrobial doses (adults and children)
       
    Fosfomycin
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
       
    Fusidic acid (Sodium fusidate)
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
    Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines (adults and children)
       
    Gentamicin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Gentamicin Charts Poster - take care you are using the right chart
    Link  National Paediatric IV Administration Guide (Medusa) - gentamicin
    Link  Paediatric cardiac surgery prophylactic antibiotics guidline
       
    Glecaprevir - Pibrentasvir (Maviret)
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • For the treatment of Hepatitis C in line with NHSE commissioning policy
     
       
    HIV formulary
    (paediatrics)
    View SPC online View childrens BNF
    Restricted Drug Restricted
    High Cost Medicine
  • See link below for further information on available products, administration advice and other guidance

  • Includes: abacavir, atazanavir, cobicistat, co-trimoxazole, darunavir, didanosine, dolutegravir, efavirenz, elvitegravir, emtricitabine, enfuviritide, etravirine,fosamprenavir, lamivudine, lopinavir, maraviroc, nevirapine, raltegravir, rilpivirine, ritonavir, stavudine, tenofovir, zidovudine

  • Includes combination products: Atripla, Combivir, Descovy, Eviplera, Evotaz, Genvoya, Kivexa, Odefsy, Rezolsta, Stribilid, Triumeq, Trizivir, Truvada  
  • Link  Paediatric HIV Formulary guidance
    Link  Post exposure prophylaxis guideline (NHS access only)
    Link  HIV drug interactions checker (Liverpool Uni)
       
    Imipenem (with cilastatin) (Primaxin)
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
       
    Itraconazole
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Leeds Cystic Fibrosis Oral antimicrobial guidelines (adults and children)

     
       
    Ledipasvir - Sofosbuvir (Harvoni)
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • For the treatment of Hepatitis C in line with NHSE commissioning policy
     
       
    Linezolid
    (paediatrics)
    View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    • weekly full blood counts required, including post-discharge (see guideline)
     
    Link  National Paediatric IV Administration Guide (Medusa) - linezolid
    Link  Linezolid - antimicrobial prescribing guidelines
    Link  LTHT Cystic Fibrosis Oral antimicrobial therapy (adults and children)
       
    Meropenem
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  PICU Prescribing and Administration Guide (meropenem)
    Link  BNFc dosing (meropenem)
    Link  LTHT Cystic Fibrosis Inhaled therapy (adults and children)
    Link  LTHT Cystic Fibrosis IV antimicrobial guidance (adults and children)
       
    Metronidazole
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  BNFC dosing (metronidazole)
    Link  National Paediatric IV Administration Guide (Medusa) - metronidazole
    Link  UK Guidelines: IBD in children
    Link  Warning: Metronidazole, Paracetamol and Sodium Chloride infusions look very similar
       
    Minocycline (cystic fibrosis)
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
       
    Moxifloxacin
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Red - When used for tuberculosis / cystic fibrosis

     
    Link  MHRA Drug Safety Update: Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
       
    Piperacillin-tazobactam
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
       
    Posaconazole (Noxafil)
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    • Treatment of invasive fungal infections including aspergillosis in patients who are refractory or intolerant to amphotericin B or itraconazole
    • Note significant differences in bioavailability between liquids and tablets - briefing includes dosing advice (LTHT access only)
     
    Link  Leeds Cystic Fibrosis Oral antimicrobial guidelines
    Link  MHRA Drug Safety Update (Sep 16): tablets and liquids are not interchangeable
       
    Ribavirin (Rebetol)
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    •             Life threatening viral infections
     
       
    Rifampicin
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary  
       
    Teicoplanin
    (paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary
    • May 2018 - some teicoplanin in LTHT is distributed without water for injection. Please see Caution in Use below, and use ward stock water for injection to reconstitute
     
    Link  LTHT Cystic Fibrosis IV antimicrobial guidelines (adults and children)
    Link  May 2018 Caution in Use - some product distributed without water for injection
    Link  National Paediatric IV administration monograph - teicoplanin
    Link  Paediatric cardiac surgery antibiotic prophylaxis guideline
       
    Temocillin
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
     
       
    Temocillin
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
       
    Tigecycline
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    Red
     
    Link  LTHT Cystic Fibrosis IV antimicrobial guidelines (adults and children)
    Link  National Paediatric IV Administration Guide (Medusa) - tigecycline
       
    Tuberculosis medicines
    (paediatrics)
    View SPC online View childrens BNF
    Formulary
    Red
     
    Link  Tuberculosis drug monographs (external link)
       
    Vancomycin
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  LTHT prescription chart - vancomycin (paediatric)
    Link  National Paediatric IV Administration Guide (Medusa) - vancomycin
    Link  Paediatric vancomycin prescribing guidance
    Link  CVC infection guideline for children on TPN
    Link  LTHT Cystic Fibrosis Inhaled Therapy (adults and children)
    Link  LTHT Cystic Fibrosis IV antimicrobial guidelines (adults and children)
       
    Vancomycin (Intrathecal)
    (paediatrics)
    View SPC online View childrens BNF
    Formulary  
    Link  CSF Shunt Infections in children
       
    Voriconazole (Vfend)
    ( paediatrics)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  MHRA Drug Safety Update (Dec 14): Voriconazole: reminder of risk of liver toxicity, phototoxicity, and squamous cell carcinoma
       
     ....
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    SMC
    Scottish Medicines Consortium
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Green

    Medicines which are appropriate for initiation and ongoing prescribing in both primary and secondary care.  

    Amber 1

    Amber Level 1- Specialist Recommendation
    These medicines are considered suitable for GP prescribing following specialist recommendation.

    There is no requirement for full Amber Drug Guidance. Generic Amber Level 1 Drug Guidance detailing responsibilities and information sources is available here
      

    Amber 2

    Amber Level 2- Specialist Initiation but no monitoring requirements
    These medicines are considered suitable for GP prescribing following specialist initiation, including titration of dose and assessment of efficacy.
    Some Amber Level 2 products will have an associated Amber Level 2 Drug Guidance document, available by clicking on the traffic light symbol to the right of the drug name. If this is not available, generic Amber Level 2 Drug Guidance is available here  

    Amber 3

    Amber Level 3- Specialist Initiation with ongoing monitoring requirements (Full Amber Drug Guidance required)
    Medicines that should be initiated by a specialist, and which require significant monitoring on an ongoing basis. Full agreement to share the care of each specific patient must be reached under the amber drug agreement, and Amber Drug Guidance must be provided to the GP (available by clicking on the traffic light symbol to the right of the drug name).   

    Red

    Guidance on the responsibilities for Red Drugs can be found here. Red Drugs would usually by prescribed by the hospital for the duration of the course. Primary care prescriber initiation or continuation of treatment not recommended except by Specialist GP and community paediatric prescribing.   

    Grey

    Grey Drugs are locally-agreed medicines which are only recommended for restricted use within the Leeds Health Economy.   

    Black

    These drugs are not recommended for use within the Leeds Health Economy  

    Multiple

    Products shown as blue have different Traffic Light List classifications dependent on indication. See the accompanying text next to the product for further information the indications for which it has a Traffic Light List classification.  

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